Winter is coming: the future of cryopreservation



Bojic, Sanja, Murray, Alex, Bentley, Barry L, Spindler, Ralf, Pawlik, Piotr, Cordeiro, Jose L, Bauer, Roman and de Magalhaes, Joao Pedro ORCID: 0000-0002-6363-2465
(2021) Winter is coming: the future of cryopreservation. BMC BIOLOGY, 19 (1). 56-.

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Abstract

The preservative effects of low temperature on biological materials have been long recognised, and cryopreservation is now widely used in biomedicine, including in organ transplantation, regenerative medicine and drug discovery. The lack of organs for transplantation constitutes a major medical challenge, stemming largely from the inability to preserve donated organs until a suitable recipient is found. Here, we review the latest cryopreservation methods and applications. We describe the main challenges-scaling up to large volumes and complex tissues, preventing ice formation and mitigating cryoprotectant toxicity-discuss advantages and disadvantages of current methods and outline prospects for the future of the field.

Item Type: Article
Uncontrolled Keywords: Cryobiology, Organ banking, Freezing, Vitrification, Biostasis
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 27 Apr 2021 15:39
Last Modified: 18 Jan 2023 22:50
DOI: 10.1186/s12915-021-00976-8
Open Access URL: https://bmcbiol.biomedcentral.com/articles/10.1186...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3120768