Electrophilic Aminating Agents in Total Synthesis



O'Neil, Lauren G and Bower, John F ORCID: 0000-0002-7551-8221
(2021) Electrophilic Aminating Agents in Total Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60 (49). pp. 25640-25666.

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Abstract

Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies have gained traction where the nitrogen source acts as an electrophile. A wide range of electrophilic aminating agents are now available, and these underpin a range of powerful C-N bond-forming processes. In this Review, we highlight the strategic use of electrophilic aminating agents in total synthesis.

Item Type: Article
Uncontrolled Keywords: C-N bonds, electrophilic amines, natural products, radicals, total synthesis
Divisions: Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 06 May 2021 15:57
Last Modified: 18 Jan 2023 22:49
DOI: 10.1002/anie.202102864
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3121772