Animal Coronaviruses Induced Apoptosis

Gioti, Katerina, Kottaridi, Christine, Voyiatzaki, Chrysa, Chaniotis, Dimitrios, Rampias, Theodoros and Beloukas, Apostolos ORCID: 0000-0001-5639-0528 (2021) Animal Coronaviruses Induced Apoptosis. LIFE-BASEL, 11 (3). 185-.

Access the full-text of this item by clicking on the Open Access link.

Text
Animal Coronaviruses Induced Apoptosis.pdf - Published version
Download (1MB) | Preview

Official URL: http://dx.doi.org/10.3390/life11030185

Abstract

Apoptosis is a form of programmed death that has also been observed in cells infected by several viruses. It is considered one of the most critical innate immune mechanisms that limits pathogen proliferation and propagation before the initiation of the adaptive immune response. Recent studies investigating the cellular responses to SARS-CoV and SARS-CoV-2 infection have revealed that coronaviruses can alter cellular homeostasis and promote cell death, providing evidence that the modulation of apoptotic pathways is important for viral replication and propagation. Despite the genetic diversity among different coronavirus clades and the infection of different cell types and several hosts, research studies in animal coronaviruses indicate that apoptosis in host cells is induced by common molecular mechanisms and apoptotic pathways. We summarize and critically review current knowledge on the molecular aspects of cell-death regulation during animal coronaviruses infection and the viral-host interactions to this process. Future research is expected to lead to a better understanding of the regulation of cell death during coronavirus infection. Moreover, investigating the role of viral proteins in this process will help us to identify novel antiviral targets related to apoptotic signaling pathways.

Item Type:	Article
Uncontrolled Keywords:	animal coronaviruses, apoptosis, apoptotic pathways
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	14 May 2021 13:23
Last Modified:	18 Jan 2023 22:47
DOI:	10.3390/life11030185
Open Access URL:	https://www.mdpi.com/2075-1729/11/3/185
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3122709