Albanese, Adam, Daly, Leonard, Mennerich, Daniela, Kietzmann, Thomas and Sée, Violaine
(2020)
The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating its Localisation, Stability and Activity.
202012.0112.v1-.
Abstract
The hypoxia signalling pathway enables adaptation of cells to decreased oxygen availability. When oxygen becomes limiting, the central transcription factors of the pathway, hypoxia-inducible factors (HIFs), are stabilised and activated to induce the expression of hypoxia-regulated genes, thereby maintaining cellular homeostasis. Whilst hydroxylation has been thoroughly described as the major and canonical modification of the HIF-α subunits, regulating both HIF stability and activity, a range of other post-translational modifications decorating the entire protein play also a crucial role in altering HIF localisation, stability, and activity. These modifications, their conservation throughout evolution and their effects on HIF-dependent signalling are discussed in this review.
Item Type: | Article |
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Uncontrolled Keywords: | Genetics, 1 Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
Depositing User: | Symplectic Admin |
Date Deposited: | 21 May 2021 08:16 |
Last Modified: | 15 Mar 2024 02:52 |
DOI: | 10.20944/preprints202012.0112.v1 |
Open Access URL: | https://doi.org/10.3390/ijms22010268 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3123435 |