HIV infection has a profound effect on hematological factors but not on electrolyte profile of Malawian adults presenting with uncomplicated malaria and severe malaria

Munyenyembe, Alinane U, Gausi, Kamunkhwala, Nyirenda, Tonney S, Hiestand, Jasmin, Mallewa, Jane and Mandala, Wilson L (2018) HIV infection has a profound effect on hematological factors but not on electrolyte profile of Malawian adults presenting with uncomplicated malaria and severe malaria. JOURNAL OF BLOOD MEDICINE, 9. pp. 153-162.

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Official URL: http://dx.doi.org/10.2147/jbm.s172869

Abstract

<h4>Aim</h4>Although malaria and HIV infections independently affect the electrolyte and hematologic profiles, little is known of how these profiles are affected in individuals coinfected with malaria and HIV. We therefore conducted this study to investigate the electrolyte and hematologic profiles of Malawian adults presenting with either uncomplicated malaria (UM), severe malaria (SM), and those presenting with HIV and UM or HIV and SM.<h4>Methods</h4>Study participants were recruited at Queen Elizabeth Central Hospital, and malaria infection was confirmed by rapid diagnostic test and malaria slides, and full blood count, HIV, and wet chemistries were analyzed.<h4>Results</h4>Sodium, potassium, calcium, and chloride levels of all 4 study groups were similar to those of healthy controls. Both HIV-infected groups (UM and SM) had lower red blood cell counts and lower hemoglobin concentration than the reference range. Platelet counts were lower in both HIV-uninfected SM cases (64×10<sup>9</sup>/L) and in the HIV-infected SM cases (66×10<sup>9</sup>/L) compared to the reference range (115-290×10<sup>9</sup>/L). HIV- UM cases had higher proportion and absolute counts of neutrophils and white blood cell counts compared to the HIV+ UM cases.<h4>Conclusion</h4>HIV infection did not affect the electrolyte profile of Malawian adults presenting with UM or SM but had an effect on red blood cells, Hb concentration, neutrophils, and platelet counts.

Item Type:	Article
Uncontrolled Keywords:	Plasmodium falciparum malaria, HIV infection, electrolytes, hematologic values, HIV-malaria co-infection, Malawian Adults
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	25 May 2021 10:03
Last Modified:	18 Jan 2023 22:44
DOI:	10.2147/JBM.S172869
Open Access URL:	https://doi.org/10.2147/JBM.S172869
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3123977