Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus

Greet, Victoria, Bode, Elizabeth ORCID: 0000-0003-3754-6026, Dukes McEwan, Joanna ORCID: 0000-0002-0326-8251, Oliveiro, Pedro, Connolly, David and Sargent, Julia (2021) Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus. Journal of Veterinary Internal Medicine, 35 (2). pp. 780-788.

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Abstract

Background Studies describing the clinical progression of animals with reverse patent ductus arteriosus (PDA) are lacking. Objectives To describe the signalment, presenting signs, echocardiographic features, and survival in a group of dogs and cats with bidirectional and continuous right-to-left PDA. Animals Forty-six client-owned animals included, comprising 43 dogs and 3 cats with bidirectional or continuous right-to-left PDA. Methods Retrospective multicenter study. Medical records and echocardiographic findings reviewed from animals diagnosed with bidirectional or continuous right-to-left PDA. Impact of ductal morphology, spectral Doppler flow profile, PCV, sildenafil treatment at presentation, sildenafil dose, severity of pulmonary hypertension, general anesthesia with or without surgery and the presence of right-sided congestive heart failure (R-CHF) on crude mortality rate were evaluated via Mantel-Cox log rank comparison of Kaplan-Meier survival curves. Univariable and multivariable Cox proportional hazards analysis was performed, and hazard ratio (HR) (95% confidence intervals [CI]) was presented. Results Hindlimb collapse was the most common presenting sign in dogs (n = 16). Clinical signs in cats were variable. Median survival time was 626 days in dogs (range 1-3628 days). Dogs with R-CHF had a shorter median survival time (58 days vs 1839 days, P = .03). Dogs treated with sildenafil at initial presentation survived longer (1839 days vs 302 days, P = .03), which was the only independent predictor of survival (HR 0.35, CI 0.15-0.86, P = 0.021). Conclusions and Clinical Importance Dogs and cats with reverse PDA have a variable clinical presentation and prognosis. Survival time was longer in animals prescribed sildenafil at diagnosis. Dogs with R-CHF at presentation have a worse overall outcome.

Item Type:	Article
Uncontrolled Keywords:	congenital heart disease, polycythemia, right-sided congestive heart failure, sildenafil
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	24 Nov 2021 10:46
Last Modified:	18 Jan 2023 22:37
DOI:	10.1111/jvim.16072
Open Access URL:	https://doi.org/10.1111/jvim.16072
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3124247

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• Clinical features and outcome of dogs and cats with bidirectional and continuous right‐to‐left shunting patent ductus arteriosus. (deposited 18 May 2021 08:13)
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