Inhibition of cortical somatosensory processing during and after low frequency peripheral nerve stimulation in humans

Hewitt, Danielle ORCID: 0000-0003-2245-4962, Byrne, Adam ORCID: 0000-0003-0761-3929, Henderson, Jessica ORCID: 0000-0002-3816-5084, Newton-Fenner, Alice, Tyson-Carr, John ORCID: 0000-0003-3364-2184, Fallon, Nicholas ORCID: 0000-0003-1451-6983, Brown, Christopher ORCID: 0000-0003-1414-2635 and Stancak, Andrej ORCID: 0000-0003-3323-3305 (2021) Inhibition of cortical somatosensory processing during and after low frequency peripheral nerve stimulation in humans. CLINICAL NEUROPHYSIOLOGY, 132 (7). pp. 1481-1495.

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Abstract

<h4>Objective</h4>Transcutaneous low-frequency stimulation (LFS) elicits long-term depression-like effects on human pain perception. However, the neural mechanisms underlying LFS are poorly understood. We investigated cortical activation changes occurring during LFS and if changes were associated with reduced nociceptive processing and increased amplitude of spontaneous cortical oscillations post-treatment.<h4>Methods</h4>LFS was applied to the radial nerve of 25 healthy volunteers over two sessions using active (1 Hz) or sham (0.02 Hz) frequencies. Changes in resting electroencephalography (EEG) and laser-evoked potentials (LEPs) were investigated before and after LFS. Somatosensory-evoked potentials were recorded during LFS and source analysis was carried out.<h4>Results</h4>Ipsilateral midcingulate and operculo-insular cortex source activity declined linearly during LFS. Active LFS was associated with attenuated long-latency LEP amplitude in ipsilateral frontocentral electrodes and increased resting alpha (8-12 Hz) and beta (16-24 Hz) band power in electrodes overlying operculo-insular, sensorimotor and frontal cortical regions. Reduced ipsilateral operculo-insular cortex source activity during LFS correlated with a smaller post-treatment alpha-band power increase.<h4>Conclusions</h4>LFS attenuated somatosensory processing both during and after stimulation.<h4>Significance</h4>Results further our understanding of the attenuation of somatosensory processing both during and after LFS.

Item Type:	Article
Uncontrolled Keywords:	EEG, Long term depression, Low frequency stimulation, Nociception, Pain
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	28 May 2021 10:10
Last Modified:	03 Feb 2023 16:20
DOI:	10.1016/j.clinph.2021.03.024
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3124345