Pappa, Olga, Kefala, Anastasia Maria, Tryfinopoulou, Kyriaki, Dimitriou, Marios, Kostoulas, Kostas, Dioli, Chrysa, Moraitou, Eleni, Panopoulou, Maria, Vogiatzakis, Evaggelos, Mavridou, Athena et al (show 2 more authors)
(2020)
Molecular Epidemiology of Multi-Drug Resistant <i>Pseudomonas aeruginosa</i> Isolates from Hospitalized Patients in Greece.
MICROORGANISMS, 8 (11).
E1652-.
Abstract
Resistant <i>Pseudomonas aeruginosa</i> isolates are one of the major causes of both hospital-acquired infections (HAIs) and community-acquired infections (CAIs). However, management of <i>P. aeruginosa</i> infections is difficult as the bacterium is inherently resistant to many antibiotics. In this study, a collection of 75 <i>P. aeruginosa</i> clinical isolates from two tertiary hospitals from Athens and Alexnadroupolis in Greece was studied to assess antimicrobial sensitivity and molecular epidemiology. All <i>P. aeruginosa</i> isolates were tested for susceptibility to 11 commonly used antibiotics, and the newly introduced Double Locus Sequence Typing (DLST) scheme was implemented to elucidate the predominant clones. The tested <i>P. aeruginosa</i> isolates presented various resistant phenotypes, with Verona Integron-Mediated Metallo-β-lactamase (VIM-2) mechanisms being the majority, and a new phenotype, FEP<sub>R</sub>-CAZ<sub>S,</sub> being reported for the first time in Greek isolates. DLST revealed two predominant types, 32-39 and 8-37, and provided evidence for intra-hospital transmission of the 32-39 clone in one of the hospitals. The results indicate that DLST can be a valuable tool when local outbreaks demand immediate tracking investigation with limited time and financial resources.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | P, aeruginosa, multi drug resistance, oprD, DLST, HAIs, FEPR-CAZ(S) |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Jun 2021 09:15 |
| Last Modified: | 03 Feb 2024 09:34 |
| DOI: | 10.3390/microorganisms8111652 |
| Open Access URL: | https://doi.org/10.3390/microorganisms8111652 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3125410 |
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