Thomas, Carol and Gwenin, Christopher D 
ORCID: 0000-0003-0363-8168
(2021)
The Role of Nitroreductases in Resistance to Nitroimidazoles.
BIOLOGY-BASEL, 10 (5).
388-.
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The Role of Nitroreductases in Resistance to Nitroimidazoles.pdf - Published version Download (2MB) | Preview |
Abstract
Antimicrobial resistance is a major challenge facing modern medicine, with an estimated 700,000 people dying annually and a global cost in excess of $100 trillion. This has led to an increased need to develop new, effective treatments. This review focuses on nitroimidazoles, which have seen a resurgence in interest due to their broad spectrum of activity against anaerobic Gram-negative and Gram-positive bacteria. The role of nitroreductases is to activate the antimicrobial by reducing the nitro group. A decrease in the activity of nitroreductases is associated with resistance. This review will discuss the resistance mechanisms of different disease organisms, including <i>Mycobacterium tuberculosis</i>, <i>Helicobacter pylori</i> and <i>Staphylococcus aureus</i>, and how these impact the effectiveness of specific nitroimidazoles. Perspectives in the field of nitroimidazole drug development are also summarised.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | nitroreductases, antimicrobial resistance, mitromidazole, metronidazole, nim genes |
| Divisions: | Faculty of Science and Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Jun 2021 15:30 |
| Last Modified: | 18 Nov 2023 02:59 |
| DOI: | 10.3390/biology10050388 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3125463 |
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