Peri-ictal magnetic resonance imaging characteristics in dogs with suspected idiopathic epilepsy

Nagendran, Aran, McConnell, James Fraser, De Risio, Luisa, Jose-Lopez, Roberto, Quintana, Rodrigo Gutierrez, Robinson, Kelsey, Platt, Simon R, Masian, Daniel Sanchez, Maddox, Thomas and Goncalves, Rita (2021) Peri-ictal magnetic resonance imaging characteristics in dogs with suspected idiopathic epilepsy. JOURNAL OF VETERINARY INTERNAL MEDICINE, 35 (2). pp. 1008-1017.

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Official URL: http://dx.doi.org/10.1111/jvim.16058

Abstract

<h4>Background</h4>The pathophysiology of changes in magnetic resonance imaging (MRI) detected after a seizure is not fully understood.<h4>Objective</h4>To characterize and describe seizure-induced changes detected by MRI.<h4>Animals</h4>Eighty-one client-owned dogs diagnosed with idiopathic epilepsy.<h4>Methods</h4>Data collected retrospectively from medical records and included anatomical areas affected, T1-, T2-weighted and T2-FLAIR (fluid-attenuated inversion recovery) appearance, whether changes were unilateral or bilateral, symmetry, contrast enhancement, mass effect, and, gray and white matter distribution. Diffusion- and perfusion weighted maps were evaluated, if available.<h4>Results</h4>Seizure-induced changes were T2-hyperintense with no suppression of signal on FLAIR. Lesions were T1-isointense (55/81) or hypointense (26/81), local mass effect (23/81) and contrast enhancement (12/81). The majority of changes were bilateral (71/81) and symmetrical (69/71). The most common areas affected were the hippocampus (39/81) cingulate gyrus (33/81), hippocampus and piriform lobes (32/81). Distribution analysis suggested concurrence between cingulate gyrus and pulvinar thalamic nuclei, the cingulate gyrus and parahippocampal gyrus, hippocampus and piriform lobe, and, hippocampus and parahippocampal gyrus. Diffusion (DWI) characteristics were a mixed-pattern of restricted, facilitated, and normal diffusion. Perfusion (PWI) showed either hypoperfusion (6/9) or hyperperfusion (3/9).<h4>Conclusions and clinical importance</h4>More areas, than previously reported, have been identified that could incur seizure-induced changes. Similar to human literature, DWI and PWI changes have been identified that could reflect the underlying metabolic and vascular changes.

Item Type:	Article
Uncontrolled Keywords:	canine, MRI, postictal, seizures
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	08 Jun 2021 07:22
Last Modified:	18 Jan 2023 22:35
DOI:	10.1111/jvim.16058
Open Access URL:	https://doi.org/10.1111/jvim.16058
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3125562