Poh, Chek Meng, Chan, Yi-Hao and Ng, Lisa FP 
ORCID: 0000-0003-4071-5222
(2020)
Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity.
FRONTIERS IN IMMUNOLOGY, 11.
287-.
Abstract
Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4<sup>+</sup> T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8<sup>+</sup>, NKT, and gamma-delta (γδ) T cells, can also contribute to protective immunity, but their effect is not actuated during the natural course of infection. This review serves to consolidate and discuss the multifaceted roles of these T cell subsets during acute and chronic phases of CHIKV infection, and highlight gaps in the current literature. Importantly, the unique characteristics of skin-resident memory T cells are outlined to propose novel prophylactic strategies that utilize their properties to provide adequate, lasting protection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chikungunya, T cells, immunopathology, vaccination, resident-memory T cells |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Jun 2021 09:00 |
| Last Modified: | 18 Jan 2023 22:35 |
| DOI: | 10.3389/fimmu.2020.00287 |
| Open Access URL: | http://doi.org/10.3389/fimmu.2020.00287 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3125838 |
Dimensions
Dimensions
