Carissimo, Guillaume, Xu, Weili, Kwok, Immanuel, Abdad, Mohammad Yazid, Chan, Yi-Hao, Fong, Siew-Wai, Puan, Kia Joo, Lee, Cheryl Yi-Pin, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah et al (show 14 more authors)
(2020)
Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19.
NATURE COMMUNICATIONS, 11 (1).
5243-.
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Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19.pdf - Published version Download (1MB) | Preview |
Abstract
SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Neutrophils, CD8-Positive T-Lymphocytes, Humans, Pneumonia, Viral, Coronavirus Infections, Receptors, Antigen, T-Cell, gamma-delta, Interleukin-6, Interleukin-10, Lymphocyte Count, Flow Cytometry, Severity of Illness Index, Immunophenotyping, Pandemics, Biomarkers, Betacoronavirus, Cytokine Release Syndrome, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 17 Jun 2021 13:53 |
| Last Modified: | 18 Jan 2023 22:34 |
| DOI: | 10.1038/s41467-020-19080-6 |
| Open Access URL: | https://www.nature.com/articles/s41467-020-19080-6 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3126738 |
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