Shahbaz, Sanaz, Foroughi, Farshad, Soltaninezhad, Ehsan, Jamialahmadi, Tannaz, Penson, Peter E 
ORCID: 0000-0001-6763-1489 and Sahebkar, Amirhossein
(2020)
Application of PLGA nano/microparticle delivery systems for immunomodulation and prevention of allotransplant rejection.
Expert Opinion on Drug Delivery, 17 (6).
pp. 767-780.
Abstract
<h4>Introduction</h4>Allograft transplantation is an effective end-point therapy to replace the function of an impaired organ. The main problem associated with allotransplantation is the induction of immune responses that results in acute and chronic graft rejection. To modulate the response of the immune system, transplant recipients generally take high dose immunosuppressant drugs for life. These drugs are associated with serious side effects such as infection with opportunistic pathogens and the development of neoplasia.<h4>Areas covered</h4>We reviewed the obstacles to successful transplantation and PLGA-based strategies to reduce immune-mediated allograft rejection.<h4>Expert opinion</h4>Biomaterial-based approaches using micro- and nanoparticles such as poly (lactic-co-glycolic acid) (PLGA) can be used to achieve controlled release of drugs. This approach decreases the required effective dose of drugs and enables local delivery of these agents to specific tissues and cells, whilst decreasing systemic effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLGA, transplantation, allograft rejection, immunosuppression |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Jun 2021 09:49 |
| Last Modified: | 18 Jan 2023 22:33 |
| DOI: | 10.1080/17425247.2020.1748006 |
| Open Access URL: | http://researchonline.ljmu.ac.uk/id/eprint/12609/ |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3127283 |
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