Gue, Ying X 
ORCID: 0000-0001-9994-8915, Ding, Wern Yew ORCID: 0000-0003-3596-6545, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Gorog, Diana A
(2021)
Assessment of endogenous fibrinolysis in clinical practice using novel tests: ready for clinical roll-out?
SN APPLIED SCIENCES, 3 (5).
524-.
Abstract
<jats:title>Abstract</jats:title><jats:p>The occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic and fibrinolytic equilibrium. The mainstay treatment of these complications involves the use of antithrombotic agents but despite advances in pharmacotherapy, there remains a significant proportion of patients who continue to remain at risk. Endogenous fibrinolysis is a physiological counter-measure against lasting thrombosis and may be measured using several techniques to identify higher risk patients who may benefit from more aggressive pharmacotherapy. However, the assessment of the fibrinolytic system is not yet accepted into routine clinical practice. In this review, we will revisit the different methods of assessing endogenous fibrinolysis (factorial assays, turbidimetric lysis assays, viscoelastic and the global thrombosis tests), including the strengths, limitations, correlation to clinical outcomes of each method and how we might integrate the assessment of endogenous fibrinolysis into clinical practice in the future.</jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Endogenous fibrinolysis, Clinical assessment, Adverse outcomes |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Jun 2021 09:48 |
| Last Modified: | 15 Mar 2024 12:03 |
| DOI: | 10.1007/s42452-021-04517-4 |
| Open Access URL: | https://doi.org/10.1007/s42452-021-04517-4 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3127286 |
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