Atrial Fibrillation Increases the Risk of Early-Onset Dementia in the General Population: Data from a Population-Based Cohort


Kim, Dongmin, Yang, Pil-Sung, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Joung, Boyoung (2020) Atrial Fibrillation Increases the Risk of Early-Onset Dementia in the General Population: Data from a Population-Based Cohort. JOURNAL OF CLINICAL MEDICINE, 9 (11). E3665-.

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Abstract

Atrial fibrillation (AF) is considered a risk factor for dementia, especially in the elderly. However, the association between the two diseases is not well identified in different age subgroups. The association of incident AF with the development of dementia was assessed from 1 January 2005, to 31 December 2013, in 428,262 participants from a longitudinal cohort (the Korea National Health Insurance Service-Health Screening cohort). In total, 10,983 participants were diagnosed with incident AF during the follow-up period. The incidence of dementia was 11.3 and 3.0 per 1000 person-years in the incident-AF and without-AF groups, respectively. After adjustment for clinical variables, the risk of dementia was significantly elevated by incident AF, with a hazard ratio (HR) of 1.98 (95% confidence interval [CI]: 1.80-2.17, <i>p</i> < 0.001), even after censoring for stroke (HR: 1.74, 95% CI: 1.55-1.94, <i>p</i> < 0.001). The HRs of incident AF for dementia onset before the age of 65 (early-onset dementia) and for onset after the age of 65 (late-onset dementia) were 2.91 (95% CI: 1.93-4.41) and 1.67 (95% CI: 1.49-1.87), respectively. Younger participants with AF were more prone to dementia development than older participants with AF (<i>p</i> for trend < 0.001). AF was associated with an increased risk of both early- and late-onset dementia, independent of clinical stroke.

Item Type: Article
Uncontrolled Keywords: atrial fibrillation, dementia, early-onset, prognosis, age
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 22 Jun 2021 09:48
Last Modified: 31 Jan 2024 17:34
DOI: 10.3390/jcm9113665
Open Access URL: https://doi.org/10.3390/jcm9113665
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3127292
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