Cardiac arrhythmias in patients with COVID-19

Wang, Yueying, Wang, Zhaojia, Tse, Gary, Zhang, Lin, Wan, Elaine Y, Guo, Yutao, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Li, Guangping, Lu, Zhibing and Liu, Tong (2020) Cardiac arrhythmias in patients with COVID-19. JOURNAL OF ARRHYTHMIA, 36 (5). pp. 827-836.

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Official URL: http://dx.doi.org/10.1002/joa3.12405

Abstract

The emergence of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major global public health concern. Although SARS-CoV-2 causes primarily respiratory problems, concurrent cardiac injury cannot be ignored since it may be an independent predictor for adverse outcomes. Cardiac arrhythmias are often observed in patients with COVID-19, especially in severe cases, and more likely contribute to the high risk of adverse outcomes. Arrhythmias should be regarded as one of the main complications of COVID-19. Mechanistically, a number of ion channels can be adversely affected in COVID-19, leading to alterations in cardiac conduction and/or repolarization properties, as well as calcium handling, which can predispose to cardiac arrhythmogenesis. In addition, several antimicrobials that are currently used as potential therapeutic agents for COVID-19, such as chloroquine, hydroxychloroquine and azithromycin, have uncertain benefit, and yet may induce electrocardiographic QT prolongation with potential ventricular pro-arrhythmic effects. Continuous electrocardiogram monitoring, accurate and prompt recognition of arrhythmias are important. The present review focuses on cardiac arrhythmias in patients with COVID-19, its underlying mechanisms, and proposed preventive and therapeutic strategies.

Item Type:	Article
Uncontrolled Keywords:	angiotensin-converting enzyme-2, arrhythmia, COVID-19, electrocardiogram, QT interval, SARS-CoV-2
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	22 Jun 2021 16:36
Last Modified:	18 Jan 2023 22:33
DOI:	10.1002/joa3.12405
Open Access URL:	https://onlinelibrary.wiley.com/doi/10.1002/joa3.1...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3127336