Effects of statins on myocarditis: A review of underlying molecular mechanisms



Parsamanesh, Negin, Karami-Zarandi, Morteza, Banach, Maciej, Penson, Peter E ORCID: 0000-0001-6763-1489 and Sahebkar, Amirhossein
(2021) Effects of statins on myocarditis: A review of underlying molecular mechanisms. PROGRESS IN CARDIOVASCULAR DISEASES, 67. pp. 53-64.

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Abstract

Myocarditis refers to the clinical and histological characteristics of a diverse range of inflammatory cellular pathophysiological conditions which result in cardiac dysfunction. Myocarditis is a major cause of mortality in individuals less than 40 years of age and accounts for approximately 20% of cardiovascular disease (CVD) events. Myocarditis contributes to dilated cardiomyopathy in 30% of patients and can progress to cardiac arrest, which has a poor prognosis of <40% survival over 10 years. Myocarditis has also been documented after infection with SARS-CoV-2. The most commonly used lipid-lowering therapies, HMG-CoA reductase inhibitors (statins), decrease CVD-related morbidity and mortality. In addition to their lipid-lowering effects, increasing evidence supports the existence of several additional beneficial, 'pleiotropic' effects of statins. Recently, several studies have indicated that statins may attenuate myocarditis. Statins modify the lipid oxidation, inflammation, immunomodulation, and endothelial activity of the pathophysiology and have been recommended as adjuvant treatment. In this review, we focus on the mechanisms of action of statins and their effects on myocarditis, SARS-CoV-2 and CVD.

Item Type: Article
Uncontrolled Keywords: Myocarditis, SARS-CoV-2, Inflammation, HMG-CoA inhibitors, RhoA
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 29 Jun 2021 08:26
Last Modified: 18 Jan 2023 21:37
DOI: 10.1016/j.pcad.2021.02.008
Open Access URL: https://researchonline.ljmu.ac.uk/id/eprint/14497/
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3128105