Serum miRNA125a-5p, miR-125b-5p, and miR-433-5p as biomarkers to differentiate between posterior circulation stroke and peripheral vertigo

Kijpaisalratana, Naruchorn, Nimsamer, Pattaraporn, Khamwut, Ariya, Payungporn, Sunchai, Pisitkun, Trairak ORCID: 0000-0001-6677-2271, Chutinet, Aurauma, Utoomprurkporn, Nattawan, Kerr, Stephen J, Vongvasinkul, Pakkawan and Suwanwela, Nijasri C (2020) Serum miRNA125a-5p, miR-125b-5p, and miR-433-5p as biomarkers to differentiate between posterior circulation stroke and peripheral vertigo. BMC NEUROLOGY, 20 (1). 372-.

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Official URL: http://dx.doi.org/10.1186/s12883-020-01946-3

Abstract

<h4>Background</h4>Acute vertigo is a common presentation of inner ear disease. However, it can also be caused by more serious conditions, especially posterior circulation stroke. Differentiating between these two conditions by clinical presentations and imaging studies during the acute phase can be challenging. This study aimed to identify serum microRNA (miRNA) candidates that could differentiate between posterior circulation stroke and peripheral vertigo, among patients presenting with acute vertigo.<h4>Methods</h4>Serum levels of six miRNAs including miR-125a-5p, miR-125b-5p, miR-143-3p, miR-342-3p, miR-376a-3p, and miR-433-5p were evaluated. Using quantitative reverse-transcription polymerase chain reaction (RT-qPCR), the serum miRNAs were assessed in the acute phase and at a 90 day follow-up visit.<h4>Results</h4>A total of 58 patients with posterior circulation stroke (n = 23) and peripheral vertigo (n = 35) were included in the study. Serum miR-125a-5p (P = 0.001), miR-125b-5p (P < 0.001), miR-143-3p (P = 0.014) and miR-433-5p (P = 0.0056) were present at significantly higher levels in the acute phase, in the patients with posterior circulation infarction. Based on the area under the receiver operating characteristic curve (AUROC) only miR-125a-5p (0.75), miR-125b-5p(0.77), and miR-433-5p (0.71) had an acceptable discriminative ability to differentiate between the central and peripheral vertigo. A combination of miRNAs revealed no significant improvement of AUROC when compared to single miRNAs.<h4>Conclusion</h4>This study demonstrated the potential of serum miR-125a-5p, miR-125b-5p, and miR-433-5p as biomarkers to assist in the diagnosis of posterior circulation infarction among patients presenting with acute vertigo.

Item Type:	Article
Uncontrolled Keywords:	Acute vertigo, Stroke biomarker, microRNA, Posterior circulation stroke, Central vertigo, Peripheral vertigo
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	12 Jul 2021 09:44
Last Modified:	18 Jan 2023 21:36
DOI:	10.1186/s12883-020-01946-3
Open Access URL:	http://doi.org/10.1186/s12883-020-01946-3
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3129735