Protein stoichiometry, structural plasticity and regulation of bacterial microcompartments

Liu, Lu-Ning ORCID: 0000-0002-8884-4819, Yang, Mengru, Sun, Yaqi and Yang, Jing (2021) Protein stoichiometry, structural plasticity and regulation of bacterial microcompartments. CURRENT OPINION IN MICROBIOLOGY, 63. pp. 133-141.

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Official URL: http://dx.doi.org/10.1016/j.mib.2021.07.006

Abstract

Bacterial microcompartments (BMCs) are self-assembling prokaryotic organelles consisting of a polyhedral proteinaceous shell and encapsulated enzymes that are involved in CO<sub>2</sub> fixation or carbon catabolism. Addressing how the hundreds of building components self-assemble to form the metabolically functional organelles and how their structures and functions are modulated in the extremely dynamic bacterial cytoplasm is of importance for basic understanding of protein organelle formation and synthetic engineering of metabolic modules for biotechnological applications. Here, we highlight recent advances in understanding the protein composition and stoichiometry of BMCs, with a particular focus on carboxysomes and propanediol utilization microcompartments. We also discuss relevant research on the structural plasticity of native and engineered BMCs, and the physiological regulation of BMC assembly, function and positioning in native hosts.

Item Type:	Article
Uncontrolled Keywords:	Organelles, Bacteria, Bacterial Proteins
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	02 Aug 2021 07:48
Last Modified:	18 Jan 2023 21:34
DOI:	10.1016/j.mib.2021.07.006
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3131978