Redispersible nanosuspensions as a plausible oral delivery system for curcumin

Elbaz, Nancy M, Tatham, Lee M ORCID: 0000-0001-9448-8876, Owen, Andrew ORCID: 0000-0002-9819-7651, Rannard, Steve ORCID: 0000-0002-6946-1097 and McDonald, Tom O ORCID: 0000-0002-9273-9173 (2021) Redispersible nanosuspensions as a plausible oral delivery system for curcumin. Food Hydrocolloids, 121. p. 107005.

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Abstract

Curcumin is widely used as a nutraceutical ingredient in food and beverage products. It has been reported that curcumin has a broad spectrum of biological activities such as anticancer, anti-inflammatory, antioxidant, and antibacterial effects. Despite the potent therapeutic effect of curcumin, its low aqueous solubility, stability, and oral bioavailability limits its effectiveness. In order to improve the physical and chemical properties of curcumin, we have formulated curcumin as a nanosuspension by using the emulsion templated freeze-drying technique. This approach produces a solid that can be dispersed as required to form a nanosuspension. The formulations were investigated in a screening process using various excipients, resulting in the identification of one curcumin nanosuspension sample which contained only polyethylene glycol (PEG) as the excipient. This formulation exhibited a small diameter (211 nm), low polydispersity (0.06) and zeta potential of −25 mV and was therefore chosen for further in vitro investigations. Various experimental parameters such as active agent and excipient concentrations, and sonication time were varied to tune the size and polydispersity of the chosen formulation. The resulting nanosuspension showed an improved chemical stability at pH values that mimic the gastrointestinal tract. An in vitro bioaccessibility experiment showed that the nanosuspension formulation resulted in more dissolution of the curcumin but this was also coupled with reduced stability. Cytotoxicity studies showed that the nanosuspension offered a reduced cytotoxicity profile compared to the solubilised curcumin on both cell lines investigated. This redispersible curcumin nanosuspension formulation may provide new opportunities for the oral dosing of curcumin.

Item Type:	Article
Uncontrolled Keywords:	Curcumin, Nanosuspension, Emulsion templated freeze-drying technique, Oral delivery, Cancer
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology Faculty of Science and Engineering > School of Physical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	12 Aug 2021 09:11
Last Modified:	18 Jan 2023 21:33
DOI:	10.1016/j.foodhyd.2021.107005
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3133246