Allwood, BW, Stolbrink, M 
ORCID: 0000-0001-6091-9316, Baines, N, Louw, E, Wademan, DT, Lupton-Smith, A, Nel, S, Maree, D, Mpagama, S, Osman, M et al (show 5 more authors)
(2021)
Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 25 (4).
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Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function.pdf - Published version Download (306kB) | Preview |
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Persistent chronic respiratory symptoms despite TB cure is poorly correlated with lung function.pdf - Published version Download (306kB) | Preview |
Abstract
<b>BACKGROUND:</b> Persistent respiratory symptoms and lung function deficits are common after patients with TB. We aimed to define the burden of post-TB lung disease (PTLD) and assess associations between symptoms and impairment in two high TB incidence communities.<b>METHODS:</b> This was a cross-sectional survey of adults in Cape Town, South Africa who completed TB treatment 1-5 years previously. Questionnaires, spirometry and 6-minute walking distance (6MWD) were used to assess relationships between outcome measures and associated factors.<b>RESULTS:</b> Of the 145 participants recruited (mean age: 42 years, range: 18-75; 55 [38%] women), 55 (38%) had airflow obstruction and 84 (58%) had low forced vital capacity (FVC); the mean 6MWD was 463 m (range: 240-723). Respiratory symptoms were common: chronic cough (<i>n</i> = 27, 19%), wheeze (<i>n</i> = 61, 42%) and dyspnoea (modified MRC dyspnoea score 3 or 4: <i>n</i> = 36, 25%). There was poor correlation between FVC or obstruction and 6MWD. Only low body mass index showed consistent association with outcomes on multivariable analyses. Only 19 (13%) participants had a diagnosis of respiratory disease, and 16 (11%) currently received inhalers.<b>CONCLUSION:</b> There was substantial burden of symptoms and physiological impairment in this "cured" population, but poor correlation between objective outcome measures, highlighting deficits in our understanding of PTLD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | post-TB, spirometry, restriction, physi-ology, obstruction, physiology |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 22 Sep 2021 10:27 |
| Last Modified: | 17 Mar 2024 11:41 |
| DOI: | 10.5588/ijtld.20.0906 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3137916 |
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