Jackson, Ben, Boni, Maciej F, Bull, Matthew J, Colleran, Amy, Colquhoun, Rachel M, Darby, Alistair C 
ORCID: 0000-0002-3786-6209, Haldenby, Sam, Hill, Verity, Lucaci, Anita, McCrone, John T et al (show 14 more authors)
(2021)
Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic.
Cell, 184 (20).
5179-+.
Abstract
We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances, there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of 2 months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7's set of mutations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19 Genomics UK (COG-UK) Consortium, Humans, Computational Biology, Phylogeny, Recombination, Genetic, Base Sequence, Gene Frequency, Genotype, Mutation, Polymorphism, Single Nucleotide, Genome, Viral, Pandemics, United Kingdom, Whole Genome Sequencing, COVID-19, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 Feb 2022 11:48 |
| Last Modified: | 03 Oct 2023 08:32 |
| DOI: | 10.1016/j.cell.2021.08.014 |
| Open Access URL: | https://doi.org/10.1016/j.cell.2021.08.014 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3138676 |
Dimensions
Dimensions
