McNaughton, Anna, Paton, Robert, Edmans, Matthew, Youngs, Jonathan, Wellens, Judith, Phalora, Prabhjeet, Fyfe, Alex, Belij-Rammerstorfer, Sandra, Bolton, Jai, Ball, Jonathan et al (show 47 more authors)
(2021)
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses.
[Preprint]
Abstract
<h4>Summary</h4> It is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-coronaviruses in the S2 subunit of the SARS-CoV-2 spike protein. This immune response is associated with the compromised production of a de novo SARS-CoV-2 spike response among individuals with fatal COVID-19 outcomes.
| Item Type: | Preprint |
|---|---|
| Additional Information: | Source info: CP-COMMUNITY-D-21-00179 |
| Uncontrolled Keywords: | OPTIC consortium, SNBTS consortium, ISARIC4C Investigators |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Sep 2021 08:00 |
| Last Modified: | 18 Jan 2023 21:27 |
| DOI: | 10.1101/2021.05.04.21256571 |
| Open Access URL: | https://www.medrxiv.org/content/10.1101/2021.05.04... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3138711 |
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