Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020



Flood, Jessica, Shingleton, Joseph, Bennett, Emma, Walker, Brodie, Amin-Chowdhury, Zahin, Oligbu, Godwin, Avis, Jacob, Lynn, Richard M, Davis, Peter, Bharucha, Tara
et al (show 13 more authors) (2021) Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020. LANCET REGIONAL HEALTH-EUROPE, 3. 100075-.

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Abstract

<h4>Background</h4>Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland.<h4>Methods</h4>Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included.<h4>Findings</h4>There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died.<h4>Interpretation</h4>The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS.<h4>Funding</h4>PHE.

Item Type: Article
Additional Information: Source info: THELANCETID-D-21-00212
Uncontrolled Keywords: Biodefense, Pediatric, Prevention, Infectious Diseases, Vaccine Related, Emerging Infectious Diseases, 2 Aetiology, 2.4 Surveillance and distribution, 3 Good Health and Well Being
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2021 07:59
Last Modified: 15 Mar 2024 16:44
DOI: 10.1016/j.lanepe.2021.100075
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138713