Flood, Jessica, Shingleton, Joseph, Bennett, Emma, Walker, Brodie, Amin-Chowdhury, Zahin, Oligbu, Godwin, Avis, Jacob, Lynn, Richard M, Davis, Peter, Bharucha, Tara et al (show 13 more authors)
(2021)
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS): Prospective, national surveillance, United Kingdom and Ireland, 2020.
LANCET REGIONAL HEALTH-EUROPE, 3.
100075-.
Text
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) Prospective, national surveilla.pdf - Published version Download (1MB) | Preview |
Abstract
<h4>Background</h4>Paediatric Multisystem Inflammatory Syndrome temporally associated with SARS-CoV-2 (PIMS-TS), first identified in April 2020, shares features of both Kawasaki disease (KD) and toxic shock syndrome (TSS). The surveillance describes the epidemiology and clinical characteristics of PIMS-TS in the United Kingdom and Ireland.<h4>Methods</h4>Public Health England initiated prospective national surveillance of PIMS-TS through the British Paediatric Surveillance Unit. Paediatricians were contacted monthly to report PIMS-TS, KD and TSS cases electronically and complete a detailed clinical questionnaire. Cases with symptom onset between 01 March and 15 June 2020 were included.<h4>Findings</h4>There were 216 cases with features of PIMS-TS alone, 13 with features of both PIMS-TS and KD, 28 with features of PIMS-TS and TSS and 11 with features of PIMS-TS, KD and TSS, with differences in age, ethnicity, clinical presentation and disease severity between the phenotypic groups. There was a strong geographical and temporal association between SARS-CoV-2 infection rates and PIMS-TS cases. Of those tested, 14.8% (39/264) children had a positive SARS-CoV-2 RT-PCR, and 63.6% (75/118) were positive for SARS-CoV-2 antibodies. In total 44·0% (118/268) required intensive care, which was more common in cases with a TSS phenotype. Three of five children with cardiac arrest had TSS phenotype. Three children (1·1%) died.<h4>Interpretation</h4>The strong association between SARS-CoV-2 infection and PIMS-TS emphasises the importance of maintaining low community infection rates to reduce the risk of this rare but severe complication in children and adolescents. Close follow-up will be important to monitor long-term complications in children with PIMS-TS.<h4>Funding</h4>PHE.
Item Type: | Article |
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Additional Information: | Source info: THELANCETID-D-21-00212 |
Uncontrolled Keywords: | Biodefense, Pediatric, Prevention, Infectious Diseases, Vaccine Related, Emerging Infectious Diseases, 2 Aetiology, 2.4 Surveillance and distribution, 3 Good Health and Well Being |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 30 Sep 2021 07:59 |
Last Modified: | 15 Mar 2024 16:44 |
DOI: | 10.1016/j.lanepe.2021.100075 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3138713 |