Antibacterial, remineralizing zinc oxide-doped phosphate-based glasses



Rajadorai, Sindhuja, Harris, Genevieve, Robinson, Alistair, Miles, Emma J, Roberts, Jonathan M, Cooper, Lee, Neel, Ensanya A Abou, Higham, Susan M ORCID: 0000-0002-4097-4702, Flannigan, Norah L and Valappil, Sabeel P ORCID: 0000-0001-9646-8406
(2022) Antibacterial, remineralizing zinc oxide-doped phosphate-based glasses. MATERIALS LETTERS, 306. p. 130813.

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Abstract

This study reports a novel melt quenched zinc oxide-doped phosphate-based glasses (Zn-PBGs) of varying CaO mol% designated as C11, C12, C13. The glass degradation rate, ions release, antibacterial activity against S. mutans and remineralization potential were investigated. Zn-PBGs showed one order of magnitude higher degradation rate than Zn-free PBG. The highest rate was observed for C11; Na+, Ca2+, Zn2+ and P5+ release followed the same trend. The higher the Zn2+ release, the greater the S. mutans growth inhibition. C11 showed significantly lower mineral loss from enamel than positive and negative controls. Zn-PBGs could be used to reverse enamel demineralization.

Item Type: Article
Uncontrolled Keywords: Phosphate-based glasses, Zinc oxide, Antibacterial, S. mutans, enamel remineralization
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2021 07:39
Last Modified: 18 Jan 2023 21:27
DOI: 10.1016/j.matlet.2021.130813
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138726