Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease-modifying treatment, 2003-17

Esan, OB ORCID: 0000-0001-7903-8770, Schluter, DK, Phillips, R, Cosgriff, R, Paranjothy, S, Williams, D, Norman, R, Carr, SB, Duckers, J and Taylor-Robinson, D ORCID: 0000-0002-5828-7724 (2022) Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease-modifying treatment, 2003-17. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 129 (5). pp. 743-751.

Access the full-text of this item by clicking on the Open Access link.

	Text Esan et.al_Pregnancy outcomes in women with CF_BJOG_2021.docx - Author Accepted Manuscript Download (485kB)
	Text Esan et.al.Pregnancy outcomes in women with CF_Supplementary_BJOG_2021.docx - Author Accepted Manuscript Download (433kB)

Abstract

<h4>Objective</h4>To compare pregnancy rates and outcomes for women with cystic fibrosis in the UK with those of the general population and assess the effect of the introduction of disease-modifying treatment.<h4>Design</h4>A population-based longitudinal study, 2003-17.<h4>Setting</h4>United Kingdom.<h4>Population</h4>Women aged 15-44 years in the UK cystic fibrosis (CF) Registry compared with women in England and Wales.<h4>Methods</h4>We calculated pregnancy and live-birth rates for the CF population and the general population of England and Wales. For women with CF we compared pregnancy rates before and after ivacaftor was introduced in 2013. We further used CF registry data to assess pregnancy outcomes for mothers with CF, and to assess the relationship between maternal pre-pregnancy lung function and nutritional status and child gestational age.<h4>Main outcome measures</h4>Pregnancy and live-birth rates and child gestational age.<h4>Results</h4>Of 3831 women with CF, 661 reported 818 pregnancies. Compared with the general population, the pregnancy rate was 3.3 times lower in the CF population (23.5 versus 77.7 per 1000 woman-years); the live-birth rate was 3.5 times lower (17.4 versus 61.4 per 1000 woman-years) with 70% of pregnancies in CF women resulting in live births; termination of pregnancy rates were also lower (9% versus 22%). Pregnancy rates increased post-ivacaftor for eligible women with CF, from 29.7 to 45.7 per 1000 woman-years. There was no association between pre-pregnancy lung function/nutrition status and gestational age.<h4>Conclusions</h4>Pregnancy rates in women with CF are about one-third of the rates in the general population with favourable outcomes, and increased for eligible women post-ivacaftor.<h4>Tweetable abstract</h4>Pregnancy rates in women with CF are about a third of the rate in England and Wales with 70% live births. Ivacaftor increases the rate.

Item Type:	Article
Uncontrolled Keywords:	cystic fibrosis transmembrane conductance regulator modulator, cystic fibrosis, ivacaftor epidemiology, pregnancy
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	30 Sep 2021 10:36
Last Modified:	06 Feb 2024 22:16
DOI:	10.1111/1471-0528.16957
Open Access URL:	https://obgyn.onlinelibrary.wiley.com/doi/10.1111/...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3138809

Available Versions of this Item

• Pregnancy rates and outcomes amongst women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease modifying treatment, 2003-17. (deposited 30 Sep 2021 10:31)
  • Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease-modifying treatment, 2003-17. (deposited 30 Sep 2021 10:36) [Currently Displayed]