Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital



Wright, Jenny, Achana, Felix, Diwakar, Lavanya, Semple, Malcolm G ORCID: 0000-0001-9700-0418, Carroll, Will D, Baillie, Kenneth, Thompson, Christopher, Alcock, Alice and Kemp, Timothy S
(2021) Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19: a prospective, observational cohort study conducted at a UK tertiary hospital. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 111. pp. 333-335.

Access the full-text of this item by clicking on the Open Access link.

Abstract

This single-centre observational study demonstrated that lower cycle threshold (Ct) values (indicating higher viral loads) on admission to hospital were associated with poorer outcomes in unvaccinated, hospitalized patients with coronavirus disease 2019 (COVID-19). Demographic and outcome data were collected prospectively for all adult patients who tested positive for severe acute respiratory syndrome coronavirus-2 on admission to the University Hospitals North Midlands NHS Trust between 1 February and 1 July 2020. Nasopharyngeal swab samples were obtained, and a valid Ct value was determined for all patients using the Viasure reverse transcription polymerase chain reaction assay, validated by Public Health England, on admission to hospital. Multi-variable logistic regression results based on data from 618 individuals demonstrated a significant inverse relationship between the odds of death and Ct values (adjusted odds ratio 0.95, 95% confidence interval 0.92-0.98, P=0.001). The association remained highly significant after adjusting for known clinical risk factors for COVID-19.

Item Type: Article
Uncontrolled Keywords: COVID-19, Respiratory infection, Viral infection
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 01 Oct 2021 07:00
Last Modified: 18 Jan 2023 21:27
DOI: 10.1016/j.ijid.2021.08.022
Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83641...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3138829