Asiimwe, Innocent Gerald 
ORCID: 0000-0002-1196-1822, Kiiza, Daniel, Walimbwa, Stephen and Sekaggya, Christine Wiltshire
(2021)
Genetic factors associated with tuberculosis-related clinical outcomes in HIV-infected Black-African patients: a systematic review and meta-analysis.
PHARMACOGENOMICS, 22 (15).
pp. 997-1017.
Abstract
<b>Aim:</b> To evaluate the genetic factors influencing tuberculosis (TB) clinical outcomes in HIV-infected Black African patients. <b>Materials & methods:</b> We systematically searched and identified eligible publications from >550 databases indexed through February 2021. <b>Results:</b> Eighteen studies were included in the qualitative synthesis. Only two cohorts from one study were included in quantitative synthesis of which the low expression <i>MIF-794 CATT5,6</i> (<i>5/5</i> + <i>5/6</i> + <i>6/6</i>) genotypes were not associated with TB infectivity in HIV-infected patients (OR: 1.31, 95% CI: 0.46-3.79). Other TB clinical outcomes observed in HIV/TB co-infected patients included: drug-induced liver injury, peripheral neuropathy, mortality, lung function and TB cure. <b>Conclusion:</b> This review finds inconclusive evidence that genetic factors are associated with TB clinical outcomes among HIV-infected patients in sub-Saharan Africa.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Genetics, HIV, AIDS, meta-analysis, systematic review, tuberculosis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Oct 2021 07:14 |
| Last Modified: | 22 Apr 2024 13:38 |
| DOI: | 10.2217/pgs-2021-0096 |
| Open Access URL: | https://www.futuremedicine.com/doi/10.2217/pgs-202... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3139295 |
Dimensions
Dimensions
