Kodama, Fumihiro, Yamaguchi, Hiroki, Park, Eunsil, Tatemoto, Kango, Sashika, Mariko, Nakao, Ryo, Terauchi, Yurino, Mizuma, Keita, Orba, Yasuko, Kariwa, Hiroaki et al (show 20 more authors)
(2021)
A novel nairovirus associated with acute febrile illness in Hokkaido, Japan.
NATURE COMMUNICATIONS, 12 (1).
5539-.
Abstract
The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014-2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Humans, Ixodes, Nairovirus, Virion, Fever, RNA, Viral, Antibodies, Viral, Leukocyte Count, Phylogeny, Genome, Viral, Adult, Middle Aged, Japan, Male |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Oct 2021 10:36 |
| Last Modified: | 18 Jan 2023 21:27 |
| DOI: | 10.1038/s41467-021-25857-0 |
| Open Access URL: | https://doi.org/10.1038/s41467-021-25857-0 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3139598 |
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