Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial



Pauley, Ellen, Drake, Thomas M, Griffith, David M, Sigfrid, Louise, Lone, Nazir I, Harrison, Ewen M, Baillie, J Kenneth, Scott, Janet T, Walsh, Timothy S, Semple, Malcolm G ORCID: 0000-0001-9700-0418
et al (show 1 more authors) (2023) Recovery from Covid-19 critical illness: A secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial. JOURNAL OF THE INTENSIVE CARE SOCIETY, 24 (2). pp. 162-169.

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Abstract

<h4>Background</h4>We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery.<h4>Methods</h4>We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge.<h4>Results</h4>Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15-0.76, <i>p</i>=0.01).<h4>Conclusion</h4>Fatigue may be less severe after Covid-19 than after other critical illness.

Item Type: Article
Uncontrolled Keywords: COVID-19, SARS-CoV-2, critical care, critical illness, intensive care units
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 19 Nov 2021 09:47
Last Modified: 01 Jul 2023 02:34
DOI: 10.1177/17511437211052226
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3143241