Babji, Sudhir, Sindhu, Kulandaipalayam Natarajan, Selvarajan, Sribal, Ramani, Sasirekha, Venugopal, Srinivasan, Khakha, Shainey Alokit, Hemavathy, Priya, Ganesan, Santhosh Kumar, Giri, Sidhartha, Reju, Sudhabharathi et al (show 5 more authors)
(2021)
Persistence of G10P[11] neonatal rotavirus infections in southern India.
JOURNAL OF CLINICAL VIROLOGY, 144.
104989-.
Text
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Abstract
<h4>Background</h4>Neonatal rotavirus infections are predominantly caused by distinct genotypes restricted to this age-group and are mostly asymptomatic.<h4>Method</h4>Stool samples from neonates admitted for >48 h in neonatal intensive care units (NICUs) in Vellore (2014-2015) and Chennai (2015-2016) in southern India, and from neonates born at hospitals in Vellore but not admitted to NICUs (2015-2016) were tested for rotavirus by ELISA and genotyped by hemi-nested RT-PCR.<h4>Results</h4>Of 791 neonates, 150 and 336 were recruited from Vellore and Chennai NICUs, and 305 were born in five hospitals in Vellore. Positivity rates in the three settings were 49.3% (74/150), 29.5% (99/336) and 54% (164/305), respectively. G10P[11] was the commonly identified genotype in 87.8% (65/74), 94.9% (94/99) and 98.2% (161/164) of the neonates in Vellore and Chennai NICUs, and those born at Vellore hospitals, respectively. Neonates delivered by lower segment cesarian section (LSCS) at Vellore hospitals, not admitted to NICUs, had a significantly higher odds of acquiring rotavirus infection compared to those delivered vaginally [p = 0.002, OR = 2.4 (1.4-4.3)].<h4>Conclusions</h4>This report demonstrates the persistence of G10P[11] strain in Vellore and Chennai, indicating widespread neonatal G10P[11] strain in southern India and their persistence over two decades, leading to interesting questions about strain stability.
Item Type: | Article |
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Uncontrolled Keywords: | Rotavirus infection, Neonate, Nursery, G10P[11] strain |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 31 Jan 2022 14:47 |
Last Modified: | 18 Jan 2023 21:24 |
DOI: | 10.1016/j.jcv.2021.104989 |
Open Access URL: | https://doi.org/10.1016/j.jcv.2021.104989 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3143722 |