Clinical presentation, treatment and outcome of canine malignant mesothelioma: A retrospective study of 34 cases

Moberg, Hanne Larsen, Gramer, Irina, Schofield, Imogen, Blackwood, Laura, Killick, David ORCID: 0000-0002-8787-7651, Priestnall, Simon L and Guillen, Alexandra (2022) Clinical presentation, treatment and outcome of canine malignant mesothelioma: A retrospective study of 34 cases. VETERINARY AND COMPARATIVE ONCOLOGY, 20 (1). pp. 304-312.

	Text Table 6 7 (supplementary) 30.09.21 HM.docx - Submitted version Download (33kB)
	Text CMM Manuscript 29.09.21 HM.docx - Submitted version Download (43kB)

Abstract

Canine malignant mesothelioma (CMM) is a rare and aggressive tumour associated with a poor prognosis. Limited information is available regarding effective treatment options and prognostic factors. The purpose of this retrospective case series was to describe the clinical presentation, treatment and survival in a cohort of dogs with this disease and to investigate possible prognostic factors. Thirty-four dogs were included. Tachypnoea and dyspnoea due to pleural effusion were the most common presenting clinical signs. Twenty-two dogs had a subcutaneous access port placed and 25 dogs were treated with intracavitary and/or intravenous chemotherapy. The main protocols used were single-agent 5-FU (n = 14) and carboplatin single-agent or alternated with mitoxantrone (n = 10). The overall response rate (defined as more than 25% reduction in effusion volume) to chemotherapy treatment was 37% after 3-weeks and 24% after 15-weeks. The median survival time (MST) for all dogs was 195 days (95% CI 53-324). MST was 234 days for dogs receiving chemotherapy and 29 days for dogs not receiving chemotherapy. The 1-year survival rate was 22% for all dogs. Treatment with chemotherapy was the only significant prognostic factor associated with survival (p = .001). Further studies are needed to determine the optimal treatment approach for malignant mesothelioma in dogs. Nevertheless, effusion recurrence should be expected and the prognosis for these patients in the long-term is poor.

Item Type:	Article
Uncontrolled Keywords:	5-fluorouracil, carboplatin, dog, intracavitary chemotherapy, mesothelioma
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	29 Nov 2021 10:28
Last Modified:	18 Jan 2023 21:23
DOI:	10.1111/vco.12777
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3144148