Haematologic toxicity in dogs with mast cell tumours treated with vinblastine/prednisolone chemotherapy with/without radiotherapy

Stiborova, K, Treggiari, E, Amores-Fuster, I, del Busto, I, Killick, D ORCID: 0000-0002-8787-7651, Maddox, T, Marrington, M, Mason, SL and Blackwood, L (2019) Haematologic toxicity in dogs with mast cell tumours treated with vinblastine/prednisolone chemotherapy with/without radiotherapy. JOURNAL OF SMALL ANIMAL PRACTICE, 60 (9). pp. 534-542.

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Abstract

<h4>Objectives</h4>To determine whether dogs with surgically excised mast cell tumours receiving a vinblastine/prednisolone chemotherapy protocol in combination with radiation therapy are at greater risk of myelosuppression than patients receiving the chemotherapy protocol alone.<h4>Materials and methods</h4>Retrospective study of clinical records of dogs with mast cell tumours that, subsequent to surgical excision, had received combination vinblasine/prednisolone chemotherapy. Dogs were assigned to two groups: those treated with adjunctive radiotherapy and vinblastine/prednisolone (RT group) and those treated with surgery followed by vinblastine/prednisolone alone (control group). Haematology results were compared between groups.<h4>Results</h4>Forty-three cases and 43 controls of similar breed, age and bodyweight were included. Concurrent radiation and vinblastine chemotherapy did not appear to increase the risk of neutropenia, which was observed in 18.6 and 23.2% of cases in the RT and control groups, respectively.<h4>Clinical significance</h4>Radiation and vinblastine chemotherapy can be safely combined in dogs with mast cell tumours without increasing the risk of clinically important myelosuppression.

Item Type:	Article
Uncontrolled Keywords:	Mast Cells, Animals, Dogs, Neoplasms, Dog Diseases, Vinblastine, Prednisolone, Antineoplastic Combined Chemotherapy Protocols, Treatment Outcome, Retrospective Studies, Hematology
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	29 Nov 2021 10:47
Last Modified:	24 Jan 2024 23:32
DOI:	10.1111/jsap.13047
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3144152