Exploration of the Supraspinal Hypotheses about Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation: A Systematic Review


Goudman, Lisa, De Groote, Sander, Linderoth, Bengt, De Smedt, Ann, Eldabe, Sam, Duarte, Rui V and Moens, Maarten (2021) Exploration of the Supraspinal Hypotheses about Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation: A Systematic Review. JOURNAL OF CLINICAL MEDICINE, 10 (13). 2766-.

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Abstract

Despite the established efficacy and effectiveness of Spinal Cord Stimulation (SCS), there is still no consensus on the supraspinal mechanisms of action of this therapy. The purpose of this study was to systematically review previously raised hypotheses concerning supraspinal mechanisms of action of SCS based on human, animal and computational studies. Searches were conducted using four electronic databases (PubMed, EMBASE, SCOPUS and Web of Science), backward reference searching and consultation with experts. The study protocol was registered prior to initiation of the review process (PROSPERO CRD42020161531). A total of 54 publications were included, 21 of which were animal studies, and 33 were human studies. The supraspinal hypotheses (<i>n</i> = 69) identified from the included studies could be categorized into six groups concerning the proposed supraspinal hypothesis, namely descending pathways (<i>n</i> = 24); ascending medial pathway (<i>n</i> = 13); ascending lateral pathway (<i>n</i> = 10); affective/motivational influences (<i>n</i> = 8); spinal-cerebral (thalamic)-loop (<i>n</i> = 3) and miscellaneous (<i>n</i> = 11). Scientific support is provided for the hypotheses identified. Modulation of the descending nociceptive inhibitory pathways, medial and lateral pathways were the most frequently reported hypotheses about the supraspinal mechanisms of action of SCS. These hypotheses were mainly supported by studies with a high or moderate confidence in the body of evidence.

Item Type: Article
Uncontrolled Keywords: spinal cord stimulation, mechanism of action, supraspinal, systematic review
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 08 Dec 2021 10:52
Last Modified: 08 Feb 2024 22:08
DOI: 10.3390/jcm10132766
Open Access URL: https://doi.org/10.3390/jcm10132766
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3144945
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