Cuthbertson, Daniel J 
ORCID: 0000-0002-6128-0822, Koskinen, Juha, Brown, Emily, Magnussen, Costan G, Hutri-Kahonen, Nina, Sabin, Matthew, Tossavainen, Paivi, Jokinen, Eero, Laitinen, Tomi, Viikari, Jorma et al (show 2 more authors)
(2021)
Fatty liver index predicts incident risk of prediabetes, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
ANNALS OF MEDICINE, 53 (1).
pp. 1256-1264.
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Fatty liver index predicts incident risk of prediabetes, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).pdf - Published version Download (941kB) | Preview |
Abstract
<h4>Aims</h4>To investigate the association between overweight/obesity and fatty liver index (FLI) on the odds of incident prediabetes/type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in 2020 participants after 10 years follow up.<h4>Methods</h4>At baseline (in 2001) 2020 participants, males and females, aged 24-39 years, were stratified according to body mass index (BMI), normal weight (<25 kg/m<sup>2</sup>), overweight (≥25-<30 kg/m<sup>2</sup>), or obese (≥30 kg/m<sup>2</sup>) and FLI (as high FLI ≥60 or low FLI <60). We examined the incidence of prediabetes/type 2 diabetes and NAFLD (ultrasound assessed) over 10 years to 2011 to determine the relative impact of FLI and BMI.<h4>Results</h4>514 and 52 individuals developed prediabetes and type 2 diabetes during follow-up. Such individuals were older, with higher BMI, serum glucose, insulin, alanine aminotransferase (ALT) and triglyceride (TG) concentrations than those who did not develop prediabetes or type 2 diabetes (<i>n</i> = 1454). The additional presence of high FLI significantly increased the risk of developing prediabetes and type 2 diabetes above the risk of being overweight/obese. Compared with normal weight, low FLI participants, the odds of prediabetes were ∼2-fold higher and the odds of type 2 diabetes were 9-10-fold higher respectively in the overweight/obese, high FLI group. No difference was observed between normal weight, low FLI and overweight/obese and low FLI groups.<h4>Conclusions</h4>An increased FLI significantly increases the odds of incident prediabetes, type 2 diabetes and NAFLD in individuals with overweight/obese highlighting the contributory role of liver fat accumulation in the pathophysiology of prediabetes/type 2 diabetes.Key messagesObesity is a risk factor for non-alcoholic fatty liver disease (NAFLD), prediabetes and type 2 diabetes.Additionally, NAFLD is more prevalent in people with prediabetes and type 2 diabetes when compared to age- and BMI-matched individuals.The presence of a raised fatty liver index (FLI) confers a significantly increased risk of developing prediabetes, type 2 diabetes and NAFLD above that conferred by being overweight/obese.The degree of elevation of FLI can risk stratify for incident prediabetes and type 2 diabetes in people with obesity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Non-alcoholic fatty liver disease, metabolic syndrome, obesity, risk, type 2 diabetes |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 16 Dec 2021 14:21 |
| Last Modified: | 18 Jan 2023 21:19 |
| DOI: | 10.1080/07853890.2021.1956685 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3145504 |
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