Romiti, Giulio Francesco, Corica, Bernadette 
ORCID: 0000-0001-9460-4435, Lip, Gregory YH ORCID: 0000-0002-7566-1626 and Proietti, Marco ORCID: 0000-0003-1452-2478
(2021)
Prevalence and Impact of Atrial Fibrillation in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.
JOURNAL OF CLINICAL MEDICINE, 10 (11).
2490-.
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Prevalence and Impact of Atrial Fibrillation in Hospitalized Patients with COVID-19 A Systematic Review and Meta-Analysis.pdf - Published version Download (1MB) | Preview |
Abstract
<h4>Background</h4>In patients with COVID-19, cardiovascular complications are common and associated with poor prognosis. Among these, an association between atrial fibrillation (AF) and COVID-19 has been described; however, the extent of this relationship is unclear. The aim of this study is to investigate the epidemiology of AF in COVID-19 patients and its impact on all-cause mortality.<h4>Methods</h4>A systematic review and meta-analysis were performed and reported according to PRISMA guidelines, and a protocol for this study was registered on PROSPERO (CRD42021227950). PubMed and EMBASE were systematically searched for relevant studies. A random-effects model was used to estimate pooled odds ratios (OR) and 95% confidence intervals (CI).<h4>Results</h4>Overall, 31 studies were included in the analysis, with a total number of 187,716 COVID-19 patients. The prevalence of AF was found to be as high as 8% of patients with COVID-19 (95% CI: 6.3-10.2%, 95% prediction intervals (PI): 2.0-27.1%), with a high degree of heterogeneity between studies; a multiple meta-regression model including geographical location, age, hypertension, and diabetes showed that these factors accounted for more than a third of the heterogeneity. AF COVID-19 patients were less likely to be female but more likely older, hypertensive, and with a critical status than those without AF. Patients with AF showed a significant increase in the risk of all-cause mortality (OR: 3.97, 95% CI: 2.76-5.71), with a high degree of heterogeneity. A sensitivity analysis focusing on new-onset AF showed the consistency of these results.<h4>Conclusions</h4>Among COVID-19 patients, AF is found in 8% of patients. AF COVID-19 patients are older, more hypertensive, and more likely to have a critical status. In COVID-19 patients, AF is associated with a 4-fold higher risk of death. Further studies are needed to define the best treatment strategies to improve the prognosis of AF COVID-19 patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | atrial fibrillation, COVID-19, prognosis, outcomes |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Dec 2021 16:12 |
| Last Modified: | 01 Feb 2024 00:46 |
| DOI: | 10.3390/jcm10112490 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3145707 |
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