The middle cerebral artery blood velocity response to acute normobaric hypoxia occurs independently of changes in ventilation in humans

AlSalahi, Sultan E, Junejo, Rehan T ORCID: 0000-0002-0670-8339, Bradley, Chris, Balanos, George M, Siebenmann, Christoph and Fisher, James P (2021) The middle cerebral artery blood velocity response to acute normobaric hypoxia occurs independently of changes in ventilation in humans. EXPERIMENTAL PHYSIOLOGY, 106 (4). pp. 861-867.

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Official URL: http://dx.doi.org/10.1113/ep089127

Abstract

<h4>New findings</h4>What is the central question of this study? Does the ventilatory response to moderate acute hypoxia increase cerebral perfusion independently of changes in arterial oxygen tension in humans? What is the main finding and its importance? The ventilatory response does not increase middle cerebral artery mean blood velocity during moderate isocapnic acute hypoxia beyond that elicited by reduced oxygen saturation.<h4>Abstract</h4>Hypoxia induces ventilatory, cardiovascular and cerebrovascular adjustments to defend against reductions in systemic oxygen delivery. We aimed to determine whether the ventilatory response to moderate acute hypoxia increases cerebral perfusion independently of changes in arterial oxygenation. Eleven young healthy individuals were exposed to four 15 min experimental conditions: (1) normoxia (partial pressure of end-tidal oxygen, PETO2 = 100 mmHg), (2) hypoxia ( PETO2 = 50 mmHg), (3) normoxia with breathing volitionally matched to levels observed during hypoxia (hyperpnoea; PETO2 = 100 mmHg) and (4) hypoxia ( PETO2<sub> </sub> = 50 mmHg) with respiratory frequency and tidal volume volitionally matched to levels observed during normoxia (i.e., restricted breathing (RB)). Isocapnia was maintained in all conditions. Middle cerebral artery mean blood velocity (MCA V<sub>mean</sub> ), assessed by transcranial Doppler ultrasound, was increased during hypoxia (58 ± 12 cm/s, P = 0.04) and hypoxia + RB (61 ± 14 cm/s, P < 0.001) compared to normoxia (55 ± 11 cm/s), while it was unchanged during hyperpnoea (52 ± 13 cm/s, P = 0.08). MCA V<sub>mean</sub> was not different between hypoxia and hypoxia + RB (P > 0.05). These findings suggest that the hypoxic ventilatory response does not increase cerebral perfusion, indexed using MCA V<sub>mean</sub> , during moderate isocapnic acute hypoxia beyond that elicited by reduced oxygen saturation.

Item Type:	Article
Uncontrolled Keywords:	blood flow, brain, heart rate, ventilation
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	21 Dec 2021 16:03
Last Modified:	13 Feb 2024 15:36
DOI:	10.1113/EP089127
Open Access URL:	https://doi.org/10.1113/EP089127
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3145812