Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation

Hegedüs, Zsófia, Hóbor, Fruzsina, Shoemark, Deborah K, Celis, Sergio, Lian, Lu-Yun, Trinh, Chi H, Sessions, Richard B, Edwards, Thomas A and Wilson, Andrew J (2021) Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation. Chemical Science, 12 (6). pp. 2286-2293.

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Official URL: http://dx.doi.org/10.1039/d0sc05694d

Abstract

<p>Dynamic ligation screening is used to identify acylhydrazone-linked peptide-fragment hybrids which bind to the SHANK1 PDZ domain with comparable affinity to the native GKAP peptide as shown by biophysical and structural analyses.</p>

Item Type:	Article
Uncontrolled Keywords:	Biotechnology
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	23 Dec 2021 08:56
Last Modified:	15 Mar 2024 05:11
DOI:	10.1039/d0sc05694d
Open Access URL:	https://doi.org/10.1039/D0SC05694D
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3145950