Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.


Gorecka, Miroslawa, McCann, Gerry P ORCID: 0000-0002-5542-8448, Berry, Colin ORCID: 0000-0002-4547-8636, Ferreira, Vanessa M, Moon, James C, Miller, Christopher A ORCID: 0000-0002-5957-7088, Chiribiri, Amedeo ORCID: 0000-0003-3394-4289, Prasad, Sanjay, Dweck, Marc R, Bucciarelli-Ducci, Chiara ORCID: 0000-0002-2515-0852 et al (show 7 more authors) (2021) Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 23 (1). 77-.

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Abstract

<h4>Background</h4>Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear.<h4>Methods</h4>COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th centile). Baseline assessment will be whilst recovering in-hospital or recently discharged, and include cardiovascular magnetic resonance (CMR) imaging, quality of life (QoL) assessments, electrocardiogram (ECG), serum biomarkers and genetics. Assessment at 6-months includes repeat CMR, QoL assessments and 6-min walk test (6MWT). The CMR protocol includes cine imaging, T1/T2 mapping, aortic distensibility, late gadolinium enhancement (LGE), and adenosine stress myocardial perfusion imaging in selected patients. The main objectives of the study are to: (1) characterise the extent and nature of myocardial involvement in COVID-19 patients with an elevated troponin, (2) assess how cardiac involvement and clinical outcome associate with recognised risk factors for mortality (age, sex, ethnicity and comorbidities) and genetic factors, (3) evaluate if differences in myocardial recovery at 6 months are dependent on demographics, genetics and comorbidities, (4) understand the impact of recovery status at 6 months on patient-reported QoL and functional capacity.<h4>Discussion</h4>COVID-HEART will provide detailed characterisation of cardiac involvement, and its repair and recovery in relation to comorbidity, genetics, patient-reported QoL measures and functional capacity.<h4>Clinical trial registration</h4>ISRCTN 58667920. Registered 04 August 2020.

Item Type: Article
Uncontrolled Keywords: COVID-HEART investigators, Humans, Pneumonia, Viral, Heart Diseases, Troponin, Contrast Media, Magnetic Resonance Imaging, Cine, Electrocardiography, Risk Factors, Longitudinal Studies, Prospective Studies, Comorbidity, Observation, Research Design, Quality of Life, Female, Male, Multicenter Studies as Topic, Myocardial Perfusion Imaging, Biomarkers, United Kingdom, Walk Test, COVID-19, SARS-CoV-2
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Clinical Directorate
Depositing User: Symplectic Admin
Date Deposited: 10 Jan 2022 16:25
Last Modified: 25 Mar 2024 05:30
DOI: 10.1186/s12968-021-00752-1
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3146259
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