Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction.

Kanagala, Prathap ORCID: 0000-0001-6739-5607, Squire, Iain B, Ng, Leong L ORCID: 0000-0002-6553-5749 and McCann, Gerry P ORCID: 0000-0002-5542-8448 (2015) Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction. International journal of cardiology. Heart & vasculature, 9. pp. 55-62.

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Abstract

Existing diagnostic guidelines for heart failure with preserved ejection fraction (<i>HFPEF</i>) primarily comprise natriuretic peptides and echocardiographic assessment, highlighting the role of diastolic dysfunction. However, recent discoveries of novel plasma markers implicated in pathophysiology of heart failure and technological advances in imaging provide additional biomarkers which are potentially applicable to <i>HFPEF</i>. The evidence base for plasma extra-cellular matrix (ECM) peptides, galectin-3, ST2, GDF-15 and pentraxin-3 is reviewed. Furthermore, the capabilities of novel imaging techniques to assess existing parameters (e.g. left ventricular ejection fraction, systolic & diastolic function, chamber size) and additional derangements of the ECM, myocardial mechanics and ischaemia evaluation are addressed.

Item Type:	Article
Uncontrolled Keywords:	Biomarkers, Extra-cellular matrix, HFPEF, Imaging, Plasma
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Clinical Directorate
Depositing User:	Symplectic Admin
Date Deposited:	11 Jan 2022 15:55
Last Modified:	15 Mar 2024 20:16
DOI:	10.1016/j.ijcha.2015.07.004
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3146264