Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study



Luo, Huanyuan, Camilleri, Dorothée, Garitaonandia, Ibon, Djumanov, Dilshat, Chen, Tao ORCID: 0000-0002-5489-6450, Lorch, Ulrike, Täubel, Jörg and Wang, Duolao
(2021) Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study. Diagnostic Microbiology and Infectious Disease, 101 (4). p. 115537.

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Abstract

We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 - 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 - 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.

Item Type: Article
Uncontrolled Keywords: COVID-19, SARS-CoV-2, coronavirus, antibody, IgG, kinetics
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 13 Jan 2022 11:47
Last Modified: 18 Jan 2023 21:16
DOI: 10.1016/j.diagmicrobio.2021.115537
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3146755

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