High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study

Walker, Lauren Elizabeth ORCID: 0000-0002-3827-4387, Sills, Graeme John, Jorgensen, Andrea ORCID: 0000-0002-6977-9337, Alapirtti, Tiina, Peltola, Jukka, Brodie, Martin J, Marson, Anthony Guy ORCID: 0000-0002-6861-8806, Vezzani, Annamaria and Pirmohamed, Munir ORCID: 0000-0002-7534-7266 (2021) High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study. EPILEPSIA, 63 (1). E1-E6.

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Abstract

Currently no sensitive and specific biomarkers exist to predict drug-resistant epilepsy. We determined whether blood levels of high-mobility group box 1 (HMGB1), a mediator of neuroinflammation implicated in drug-resistant epilepsies, identifies patients with drug-resistant seizures. Patients with drug-resistant epilepsy express significantly higher levels of blood HMGB1 than those with drug-responsive, well-controlled seizures and healthy controls. No correlation existed between blood HMGB1 levels and total pretreatment seizure count or days since last seizure at new epilepsy diagnosis, indicating that blood HMGB1 does not solely reflect ongoing seizures. HMGB1 distinguishes with high specificity and selectivity drug-resistant versus drug-responsive patients. This protein therefore has potential clinical utility to act as a biomarker for predicting response to therapy, which should be addressed in prospective clinical studies.

Item Type:	Article
Uncontrolled Keywords:	biomarker, drug-resistant, epilepsy, HMGB1, neuroinflammation
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	17 Jan 2022 10:18
Last Modified:	18 Jan 2023 21:15
DOI:	10.1111/epi.17116
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3146992