Payne, Rebecca P, Longet, Stephanie, Austin, James A, Skelly, Donal T, Dejnirattisai, Wanwisa, Adele, Sandra, Meardon, Naomi, Faustini, Sian, Al-Taei, Saly, Moore, Shona C ORCID: 0000-0001-8610-2806 et al (show 49 more authors)
(2021)
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine.
CELL, 184 (23).
5699-+.
Text
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine.pdf - Published version Download (5MB) | Preview |
Abstract
Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6-14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4<sup>+</sup> T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol.
Item Type: | Article |
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Uncontrolled Keywords: | PITCH Consortium, T-Lymphocytes, Humans, Immunoglobulin G, Vaccines, Synthetic, Antibodies, Viral, Treatment Outcome, Linear Models, Immunity, Cross-Priming, Dose-Response Relationship, Immunologic, Reference Standards, Adult, Aged, Middle Aged, Female, Male, Young Adult, Antibodies, Neutralizing, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Ethnicity, mRNA Vaccines, BNT162 Vaccine |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 17 Jan 2022 10:57 |
Last Modified: | 30 Dec 2023 03:11 |
DOI: | 10.1016/j.cell.2021.10.011 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147011 |