Castellana, Marco, Donghia, Rossella, Guerra, Vito, Procino, Filippo, Lampignano, Luisa, Castellana, Fabio, Zupo, Roberta, Sardone, Rodolfo 
ORCID: 0000-0003-1383-1850, De Pergola, Giovanni, Romanelli, Francesco et al (show 2 more authors)
(2021)
Performance of Fatty Liver Index in Identifying Non-Alcoholic Fatty Liver Disease in Population Studies. A Meta-Analysis.
JOURNAL OF CLINICAL MEDICINE, 10 (9).
1877-.
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Performance of Fatty Liver Index in Identifying Non-Alcoholic Fatty Liver Disease in Population Studies. A Meta-Analysis.pdf - Published version Download (1MB) | Preview |
Abstract
<h4>Background</h4>Fatty liver index (FLI) is a non-invasive tool used to stratify the risk of non-alcoholic fatty liver disease (NAFLD) in population studies; whether it can be used to exclude or diagnose this disorder is unclear. We conducted a meta-analysis to assess the prevalence of NAFLD in each FLI class and the performance of FLI in detecting NAFLD.<h4>Methods</h4>Four databases were searched until January 2021 (CRD42021231367). Original articles included were those reporting the performance of FLI and adopting ultrasound, computed tomography, or magnetic resonance as a reference standard. The numbers of subjects with NAFLD in FLI classes <30, 30-60, and ≥60, and the numbers of subjects classified as true/false positive/negative when adopting 30 and 60 as cut-offs were extracted. A random-effects model was used for pooling data.<h4>Results</h4>Ten studies were included, evaluating 27,221 subjects without secondary causes of fatty liver disease. The prevalence of NAFLD in the three FLI classes was 14%, 42%, and 67%. Sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio for positive results, likelihood ratio for negative results, and diagnostic odds ratio were 81%, 65%, 53%, 84%, 2.3, 0.3, and 7.8 for the lower cut-off and 44%, 90%, 67%, 76%, 4.3, 0.6, and 7.3 for the higher cut-off, respectively. A similar performance was generally found in studies adopting ultrasound versus other imaging modalities.<h4>Conclusions</h4>FLI showed an adequate performance in stratifying the risk of NAFLD. However, it showed only weak evidence of a discriminatory performance in excluding or diagnosing this disorder.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | fatty liver index, non-alcoholic fatty liver disease, steatosis, liver, meta-analysis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Jan 2022 16:02 |
| Last Modified: | 13 Feb 2024 17:13 |
| DOI: | 10.3390/jcm10091877 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147280 |
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