Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes


Oldfield, Lucy ORCID: 0000-0002-0839-402X, Evans, Anthony ORCID: 0000-0001-8547-1730, Rao, Rohith Gopala, Jenkinson, Claire, Purewal, Tejpal, Psarelli, Eftychia E, Menon, Usha, Timms, John F, Pereira, Stephen P, Ghaneh, Paula et al (show 3 more authors) (2022) Blood levels of adiponectin and IL-1Ra distinguish type 3c from type 2 diabetes: Implications for earlier pancreatic cancer detection in new-onset diabetes. EBIOMEDICINE, 75. 103802-.

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Abstract

<h4>Background</h4>Screening for pancreatic ductal adenocarcinoma (PDAC) in populations at high risk is recommended. Individuals with new-onset type 2 diabetes mellitus (NOD) are the largest high-risk group for PDAC. To facilitate screening, we sought biomarkers capable of stratifying NOD subjects into those with type 2 diabetes mellitus (T2DM) and those with the less prevalent PDAC-related diabetes (PDAC-DM), a form of type 3c DM commonly misdiagnosed as T2DM.<h4>Methods</h4>Using mass spectrometry- and immunoassay-based methodologies in a multi-stage analysis of independent sample sets (n=443 samples), blood levels of 264 proteins were considered using Ingenuity Pathway Analysis, literature review and targeted training and validation.<h4>Findings</h4>Of 30 candidate biomarkers evaluated in up to four independent patient sets, 12 showed statistically significant differences in levels between PDAC-DM and T2DM. The combination of adiponectin and interleukin-1 receptor antagonist (IL-1Ra) showed strong diagnostic potential, (AUC of 0.91; 95% CI: 0.84-0.99) for the distinction of T3cDM from T2DM.<h4>Interpretation</h4>Adiponectin and IL-1Ra warrant further consideration for use in screening for PDAC in individuals newly-diagnosed with T2DM.<h4>Funding</h4>North West Cancer Research, UK, Cancer Research UK, Pancreatic Cancer Action, UK.

Item Type: Article
Uncontrolled Keywords: Pancreatic cancer, Early detection, Type 3c diabetes, Blood biomarkers, Adiponectin, IL-1Ra
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 24 Jan 2022 16:55
Last Modified: 18 Jan 2023 21:14
DOI: 10.1016/j.ebiom.2021.103802
Open Access URL: https://www.thelancet.com/pdfs/journals/ebiom/PIIS...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3147566
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