Chan, Yi-Hao, Fong, Siew-Wai, Poh, Chek-Meng, Carissimo, Guillaume, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Goh, Yun Shan, Lim, Jackwee, Xu, Weili, Chee, Rhonda Sin-Ling et al (show 16 more authors)
(2021)
Asymptomatic COVID-19: disease tolerance with efficient anti-viral immunity against SARS-CoV-2.
EMBO MOLECULAR MEDICINE, 13 (6).
e14045-.
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Asymptomatic COVID-19 disease tolerance with efficient anti-viral immunity against SARS-CoV-2.pdf - Published version Download (3MB) | Preview |
Abstract
The immune responses and mechanisms limiting symptom progression in asymptomatic cases of SARS-CoV-2 infection remain unclear. We comprehensively characterized transcriptomic profiles, cytokine responses, neutralization capacity of antibodies, and cellular immune phenotypes of asymptomatic patients with acute SARS-CoV-2 infection to identify potential protective mechanisms. Compared to symptomatic patients, asymptomatic patients had higher counts of mature neutrophils and lower proportion of CD169<sup>+</sup> expressing monocytes in the peripheral blood. Systemic levels of pro-inflammatory cytokines were also lower in asymptomatic patients, accompanied by milder pro-inflammatory gene signatures. Mechanistically, a more robust systemic Th2 cell signature with a higher level of virus-specific Th17 cells and a weaker yet sufficient neutralizing antibody profile against SARS-CoV-2 was observed in asymptomatic patients. In addition, asymptomatic COVID-19 patients had higher systemic levels of growth factors that are associated with cellular repair. Together, the data suggest that asymptomatic patients mount less pro-inflammatory and more protective immune responses against SARS-CoV-2 indicative of disease tolerance. Insights from this study highlight key immune pathways that could serve as therapeutic targets to prevent disease progression in COVID-19.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | asymptomatic, COVID-19, disease tolerance, SARS-CoV-2 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 27 Jan 2022 12:37 |
| Last Modified: | 25 Dec 2023 03:30 |
| DOI: | 10.15252/emmm.202114045 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147697 |
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