Lim, Jackwee, Puan, Kia Joo, Wang, Liang Wei, Teng, Karen Wei Weng, Loh, Chiew Yee, Tan, Kim Peng, Carissimo, Guillaume, Chan, Yi-Hao, Poh, Chek Meng, Lee, Cheryl Yi-Pin et al (show 23 more authors)
(2021)
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals.
FRONTIERS IN IMMUNOLOGY, 12.
710217-.
Text
Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals.pdf - Published version Download (19MB) | Preview |
Abstract
Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and Vδ2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of "long COVID-19", and defines key cells and cytokines that delineate true and quasi-convalescent states.
Item Type: | Article |
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Uncontrolled Keywords: | COVID-19, cytokine profile, severity, SARS, CoV, 2, inflammation, active infection, immunophenotyping, immune recovery |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 27 Jan 2022 15:16 |
Last Modified: | 18 Jan 2023 21:14 |
DOI: | 10.3389/fimmu.2021.710217 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147717 |