Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study



Gooden, Tiffany E, Gardner, Mike, Wang, Jingya, Jolly, Kate, Lane, Deirdre A ORCID: 0000-0002-5604-9378, Benjamin, Laura A ORCID: 0000-0002-9685-1664, Mwandumba, Henry C, Kandoole, Vanessa, Lwanga, Isaac B, Taylor, Stephen
et al (show 4 more authors) (2022) Incidence of Cardiometabolic Diseases in People With and Without Human Immunodeficiency Virus in the United Kingdom: A Population-Based Matched Cohort Study. JOURNAL OF INFECTIOUS DISEASES, 225 (8). pp. 1348-1356.

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Abstract

<h4>Background</h4>Evidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with human immunodeficiency virus (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events, and common risk factors.<h4>Methods</h4>This was a nationwide, population-based, cohort study comparing adult (≥18 years old) PWH with people without human immunodeficiency virus (HIV) matched on age, sex, ethnicity, and location. The primary outcome was composite CVD comprising stroke, myocardial infarction, peripheral vascular disease, ischemic heart disease, and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD), and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.<h4>Results</h4>We identified 9233 PWH and matched them with 35 721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR], 1.50; 95% confidence interval [CI], 1.28-1.77), stroke (aHR, 1.42; 95% CI, 1.08-1.86), ischemic heart disease (aHR, 1.55; 95% CI, 1.24-1.94), hypertension (aHR, 1.37; 95% CI, 1.23-1.53), type 2 diabetes (aHR, 1.28; 95% CI, 1.09-1.50), CKD (aHR, 2.42; 95% CI, 1.98-2.94), and all-cause mortality (aHR, 2.84; 95% CI, 2.48-3.25).<h4>Conclusions</h4>PWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.

Item Type: Article
Uncontrolled Keywords: cardiovascular disease, metabolic diseases, comorbidity, multimorbidity, HIV
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 28 Jan 2022 14:48
Last Modified: 18 Jan 2023 21:14
DOI: 10.1093/infdis/jiab420
Open Access URL: https://doi.org/10.1093/infdis/jiab420
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3147778