Thomson-Luque, Richard, Votborg-Novel, Lasse, Ndovie, Wanangwa, Andrade, Carolina M, Niangaly, Moussa, Attipa, Charalampos 
ORCID: 0000-0001-6039-6586, Lima, Nathalia F, Coulibaly, Drissa, Doumtabe, Didier, Guindo, Boureima et al (show 12 more authors)
(2021)
<i>Plasmodium falciparum</i> transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes.
NATURE COMMUNICATIONS, 12 (1).
4711-.
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Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infec.pdf - Published version Download (8MB) | Preview |
Abstract
Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falciparum's tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental cycle (IDC) to publicly available transcriptomes of parasites obtained from malaria cases of differing clinical severity across multiple studies. Our analysis shows that within each IDC, the circulation time of infected erythrocytes without sequestering to endothelial cells decreases with increasing parasitaemia or disease severity. Accordingly, we find that the size of circulating infected erythrocytes is inversely related to parasite density and disease severity. We propose that enhanced adhesiveness of infected erythrocytes leads to a rapid increase in parasite burden, promoting higher parasitaemia and increased disease severity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Erythrocytes, Humans, Plasmodium falciparum, Parasitemia, Malaria, Falciparum, Blood Circulation Time, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genes, Bacterial, Gene Ontology |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Jan 2022 15:46 |
| Last Modified: | 19 Oct 2023 08:47 |
| DOI: | 10.1038/s41467-021-25062-z |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3147900 |
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