Adipokines: inflammation and the pleiotropic role of white adipose tissue.

Trayhurn, Paul ORCID: 0000-0002-9940-283X (2022) Adipokines: inflammation and the pleiotropic role of white adipose tissue. The British journal of nutrition, 127 (2). pp. 161-164.

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Official URL: http://dx.doi.org/10.1017/s0007114521003962

Abstract

I had been working on the endocrine and signalling role of white adipose tissue (WAT) since 1994 following the identification of the ob (Lep) gene(1), this after some 15 years investigating the physiological role of brown adipose tissue. The ob gene, a mutation in which it is responsible for the profound obesity of ob/ob (Lepob/Lepob) mice, is expressed primarily in white adipocytes and encodes the pleiotropic hormone leptin. The discovery of this adipocyte hormone had wide-ranging implications, including that white fat has multiple functions that far transcend the traditional picture of a simple lipid storage organ.

Item Type:	Article
Uncontrolled Keywords:	Adipokine, Adipose tissue, Hypoxia, Inflammation, Leptin, Obesity, Oxygen, White fat
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	07 Feb 2022 08:28
Last Modified:	18 Jan 2023 21:14
DOI:	10.1017/s0007114521003962
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3148197